|Year : 2022 | Volume
| Issue : 2 | Page : 93-102
Motorized intramedullary lengthening followed by osseointegration for amputees with short residual femurs: An observational cohort study
Jason Shih Hoellwarth1, Kevin Tetsworth2, Muhammad Adeel Akhtar3, Atiya Oomatia4, Munjed Al Muderis4
1 Osseointegration Limb Replacement Center, Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY, USA
2 Department of Orthopaedic Surgery, Royal Brisbane and Women's Hospital, Queensland, Australia
3 Department of Orthopaedic Surgery, NHS Fife, Kirkcaldy, KY2 5AH, United Kingdom
4 Limb Reconstruction Centre, Macquarie University Hospital, Macquarie University, Macquarie Park, Australia
|Date of Submission||23-May-2022|
|Date of Decision||14-Jun-2022|
|Date of Acceptance||22-Jun-2022|
|Date of Web Publication||29-Dec-2022|
Jason Shih Hoellwarth
535 East 70th Street, New York, NY 10021
Source of Support: None, Conflict of Interest: None
Context: Some patients seeking transcutaneous osseointegration for amputees (TOFA) have residual bones so short there is concern whether they provide sufficient surface to support full weight. Our strategy was to lengthen these patients' femurs with a motorized intramedullary lengthening nail (MILN) before TOFA. Aims: The aim of this study is to describe 10 transfemoral amputees' experience with MILN before TOFA, focusing on the complications of MILN and TOFA, and also the patients' preoperative and postoperative quality of life (QOL). Settings and Design: A retrospective registry review of all MILN before TOFA surgeries was performed. Subjects and Methods: The patients' operative complications during/following MILN and TOFA were investigated. Furthermore, the patients' mobility (daily prosthesis wear hours, K-level, Timed Up and Go (TUG), and 6 min Walk Test [6MWT]) and QOL survey data (Questionnaire for Persons with a Transfemoral Amputation [QTFA]) were compared at the initial consultation and at the latest follow-up using Fisher's exact test for frequencies, and Student's t-test for means (significance, P < 0.05). Statistical Analysis Used: Fisher's exact test for frequencies, and Student's t-test for means (significance, P < 0.05). Results: Seven patients had one operative complication each: Three regenerate (autograft and plating), two nail malfunctions (nail replacement), one broken linkage cable (acute length correction with autografting and fixation), and one early consolidation (re-osteotomy). All ten patients had TOFA, an average of 12.0 ± 3.9 months after MILN surgery. One patient had debridement for infection (implant retained) and one patient had the implant removed due to infection. Significant mobility improvements were K-level >2 (2/9 = 22% vs. 9/10 = 90%, P =0.006) and TUG <15 s (1/8 = 13% vs. 6/8 = 75% P = 0.041). Wear hours and 6MWT improved but not significantly. All three aspects of QTFA significantly improved: Global (44.8 ± 29.9 vs. 75.9 ± 26.8, P =0.050), mobility (50.3 ± 30.8 vs. 74.8 ± 18.2, P =.033), and problem (38.8 ± 18.6 vs. 15.6 ± 18.3, P = 0.017). Conclusions: MILN before TOFA reliably achieves stable osseointegration for amputees with short residual femurs. Amputee lengthening remains demanding, but patients report significantly improved QOL and demonstrate improved mobility following TOFA. The minimum length of bone necessary to support a full weight-bearing osseointegrated prosthesis remains unknown.
Keywords: Amputee, femur, intramedullary lengthening, lengthening, osseointegration, short residuum
|How to cite this article:|
Hoellwarth JS, Tetsworth K, Akhtar MA, Oomatia A, Muderis MA. Motorized intramedullary lengthening followed by osseointegration for amputees with short residual femurs: An observational cohort study. J Limb Lengthen Reconstr 2022;8:93-102
|How to cite this URL:|
Hoellwarth JS, Tetsworth K, Akhtar MA, Oomatia A, Muderis MA. Motorized intramedullary lengthening followed by osseointegration for amputees with short residual femurs: An observational cohort study. J Limb Lengthen Reconstr [serial online] 2022 [cited 2023 Jan 29];8:93-102. Available from: https://www.jlimblengthrecon.org/text.asp?2022/8/2/93/366301
| Introduction|| |
Transcutaneous osseointegration for amputees, (TOFA) [Figure 1] consistently provides improved mobility and quality of life (QOL) for amputees compared to traditional socket prosthesis (TSP) rehabilitation., Conventionally, amputees provided this reconstructive procedure are relatively optimal candidates: Healthy, young patients with a transfemoral amputation. The force of patients' full body weight-bearing impact is transmitted through the prosthetic leg and into the intramedullary implant to the patient's skeleton, so a patient's bone must achieve sufficiently robust ingrowth to prevent the static and dynamic forces from dislodging the implant from the skeleton. The strength of the bone-implant interface is influenced by the quality and quantity of integration. The quality is affected by the implant material, its surface texture and topography, and the general metabolic health of the patient and the specific bone. The quantity is the total surface area and depth available for integration.,
|Figure 1: Pictorial summary of transcutaneous osseointegration. (a) Unassembled view of an Osseointegrated Prosthetic Limb (OPL) implant, with components arranged at the approximate proximal-distal levels in which they would be once assembled and implanted in a patient who had undergone a femoral amputation. 1, proximal cap screw; 2, OPL body; 3, safety screw; 4, dual cone abutment adapter; 5, permanent locking screw; 6, proximal connector; and 7, prosthetic connector. (b) Radiograph of OPL in a transfemoral amputee. (c) Clinical photograph of a transfemoral amputee demonstrating a healthy transcutaneous stoma for the prosthetic connection. (d) Activity representative of the stability that osseointegrated limbs can provide for amputees|
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The quantity of the surface area is mostly determined by the diameter and length of the intramedullary canal and the implant. There is very limited capacity to modify the diameter aspect of the equation. First, the diameter of the patient's bone is difficult to substantially modify because the implant must impact into the cortical bone, and many amputees have relatively thin cortices, limiting the aggressiveness of reaming. Second, deeper implant channels provide minimal additional strength but require substantially more time to ingrow and, most importantly, have increasing failure risk due to limited vascular support capacity., Length, however, is modifiable via distraction histogenesis, made more convenient by motorized intramedullary lengthening nails (MILNs). An additional benefit of a longer residual bone is better prosthetic control.
Because reliable, excellent results are routinely achievable when the textured portions of the two commercially available press-fit osseointegration implants are fully seated, we counsel patients with the short residual bone to have lengthening to optimize the area available for integration and to improve their prosthesis control. While the implant lengths could be cut shorter to accommodate a shorter residual bone, it is unknown whether this reduced length provides adequate contact to achieve stability. The two implants our group uses are the Integrated Limb Prosthesis (ILP, Orthodynamic, Lubeck, Germany) whose standard stem length is 140 mm, and the Osseointegrated Prosthetic Limb (OPL, Permedica Medical Manufacturing, Lecco, Italy) whose standard stem length is 160 mm.
This study reports our experience with a consecutive series of the first 10 transfemoral amputees who sought osseointegration from us but had a residual bone of approximately the minimum implant length or less. These patients had MILN lengthening followed by TOFA. The primary purpose of this article is to evaluate the safety profile of "lengthening before osseointegration" as a reconstructive strategy for such patients. In addition, this article describes the change in mobility, QOL, and complications experienced by these patients between their presentation and their most recent follow-up visit.
| Subjects and Methods|| |
Following institutional ethics review, we retrospectively reviewed our prospectively maintained osseointegration database. In general, patients considered for osseointegration are skeletally mature adults who either (1) report pain or mobility dissatisfaction with their TSP; (2) have an intact limb with incapacitating pain, complex deformity, or profound distal weakness, whose functional capacity is considered likely to be improved by amputation; or (3) are recent amputees preferring osseointegration to TSP rehabilitation. Patients included in this study had MILN lengthening before osseointegration at our primary medical center; patients who did not have lengthening or whose procedures were performed at outreach locations were excluded. [Table 1] summarizes the patients included in this study.
Amputees interested in TOFA were counseled about the typical risks and benefits of the reconstruction procedure; patients with residual bones shorter than the standard length of the implants were counseled that very few patients worldwide had such short limbs prior to osseointegration, limiting the knowledge available to provide specific counseling. It was recommended to increase the length of their residual bone to provide more surface area for ingrowth into the implant, which would be expected to confer a better likelihood of permanent stable ingrowth. Patients were informed this would require at least two surgeries: The first to insert the MILN, followed by a period of lengthening and consolidation which would take at minimum several months, followed by a second surgery to remove the MILN and insert the osseointegration implant. Patients were counseled that amputee lengthening was more challenging than lengthening patients with intact limbs, and additional surgeries could be necessary to address issues such as regenerate quality or implant malfunction. Patients were informed that each of these surgeries was rare worldwide, and there were no known reports of this combination of procedures.
MILN lengthening was performed using a 14 mm × 130 mm telescopic nail (Freedom Residual Limb Lengthening device, NuVasive, San Diego, CA). The techniques and considerations have been previously detailed and summarized as follows. The fundamental goal of MILN for these patients was to create a bone with at least 140 or 160 mm, to fit the standard sized implant. We predominantly used the ILP early in our experience, but preferred the OPL later on, as the OPL's titanium composition facilitates osseointegration better than cobalt-chrome, and the proportionally thicker inner diameter of the OPL being more robust against implant fracture. The surgical exposure for the MILN was via the distal residual limb. The osteotomy site was predrilled, retrogradely reamed, and the osteotomy completed with osteotomes. MILNs were generally inserted in an antegrade implant orientation, in a retrograde surgical approach from the amputated femur's distal end. There are several reasons for a retrograde approach. Most importantly, all osseointegration is performed from a retrograde direction, so a distal surgical approach would be necessary eventually. Second, a distal incision is often necessary to visualize the distal linkage of nail to lengthening fragment. It is also faster and more visible to approach retrograde. By not violating the piriformis fossa bone, it can offer a backup support in situations where bone that is osteopenic from long-term amputation may lose proximal cross screw purchase. Finally, less radiation from image intensification is needed to place and secure the nail. Multiple blocking screws were often used to reduce malorientation during lengthening. Bones shorter than the MILN required linkage techniques such as cables [Figure 2] or bent locking plates [Figure 3]. Lengthening commenced after 7 days, at a maximum amount of 1 mm daily in divided episodes. Radiographic follow-up was performed weekly or biweekly until the goal length or the nail's maximum stroke length was achieved. Regenerate was generally considered adequate for MILN exchange for osseointegration when four cortices were clearly confluent on perpendicular radiographs.
|Figure 2: Radiographic summary of the MILN and TOFA experience for Patient 4. (a) Immediate postoperative radiograph identifying the MILN is longer than the bone requiring a custom linkage technique, in this case multiple cerclage cables. (b) The patient gained 26 mm over 7 months, but (c) the cables then broke and the distal bone segment collapsed 30 mm. (d) A procedure to harvest left femur intramedullary autograft and place it between the bone segments which were plated to length was performed. (e) TOFA was performed 4 months later and has remained stable in the 41 months since|
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|Figure 3: Radiographic summary of patient 10 depicting the contoured plate linkage technique. (a) Immediate postoperative radiograph identifying the MILN is longer than the bone, in this case linked using a locking plate. (b) The plate (arrow) is fixed to the bone with multiple locking screws, including a rather long retrograde screw (star) which provides a long purchase distance. A screw links the plate to the nail via the distal nail hole (arrowhead). (c) Although this patient's original nail had mechanical problems requiring exchange, subsequent lengthening proceeded uneventfully (40 mm in 6 weeks). (d) He had TOFA performed after 3.7 months after MILN and has done well in the 34 months since. (e) This patient's right femur was long enough for TOFA without prior MILN|
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Data were gathered as follows. At the preoperative consultation, patients had their Medicare Functional Classification Level (K-level) determined by the surgeons. Research assistants administered QOL surveys (Questionnaire for Persons with a Transfemoral Amputation, [QTFA]) and formal mobility tests. Mobility was assessed by the Timed Up and Go, (TUG) and 6-min walk test, (6MWT). Following osseointegration, patients were followed up clinically at 3 weeks, 3 months, 6 months, and annually. Formal K-level, survey, and mobility data was determined at annual time points. Although we encourage every patient to complete the data metrics to optimize our care for them and others, osseointegration surgery was not withheld from patients who declined completing surveys and formal mobility tests at any time point. They were still enrolled in our registry to optimize follow-up efforts and track complications, and their missing data was excluded from statistical comparisons. Complications were defined as any unplanned surgery to the individual extremity, such as to address infection or implant issues. Frequency comparison was performed using Fisher's exact test (QuickCalcs, GraphPad Software, San Diego, CA), and means were compared using Student's t-test (Google Sheets, Alphabet Inc., Mountain View, CA); significance was defined as P < 0.05.
| Results|| |
[Table 2] summarizes the MILN experience. Patients 8 and 9 had starting lengths that were borderline adequate for a standard implant, but were lengthened to optimize the lever arm of the amputated limb. Four of the eight (50%) patients who were shorter than the standard implant length achieved the ideal minimum length. Seven patients (70%) experienced one complication each prompting unplanned surgery. The first three patients had an additional procedure to supplement radiographically meager regenerate with autograft bone; this topic will be expounded upon in the Discussion. Two patients (7 and 10) had nail malfunction prompting implant exchange. Patient 4's linkage cables broke, prompting plate stabilization with autograft [Figure 2]. Patient 9 had early consolidation prompting re-osteotomy. The duration of lengthening and therefore lengthening index are not reported due to the high rate of additional surgery, obfuscating the usefulness of such metrics.
[Table 3] summarizes the osseointegration experience. All 10 patients (100%) successfully received their osseointegration implant and achieved unassisted ambulation. Eight of 10 (80%) had no postosseointegration complications. One patient had debridement with implant retention, and another patient developed infection which eventually prompted implant removal; revision osseointegration was not performed for this patient.
[Table 4] reports the mobility performance of patients before lengthening and after osseointegration. Overall, there was improvement in all mobility metrics. The daily wear hours improved as a cohort, although not to significant confidence [Figure 4]. The improvements of K-level [Figure 5] and TUG [Figure 6] were significant. The 6MWT also improved as a cohort, but not to significant confidence [Figure 7]. It is notable that all the patients who started as wheelchair-bound gained and achieved independent ambulation capacity; the patient whose implant required removal did achieve independent ambulation, but following removal he did not have revision osseointegration and returned to being wheelchair-bound because he had pain related to attempted prosthesis wear along with irremediable socket fit problems. In addition, no K-levels decreased.
|Figure 4: Daily prosthesis wear hours. The lines depict each patient's before and after situation, with line thickness reflective of patient number. The flanking histograms identify the patient situation distribution. The proportion of patients wearing their prosthesis at least 10 h daily increased, but not to a significant level|
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|Figure 5: Physician-determined K-level. The lines depict each patient's before and after situation, with line thickness reflective of patient number. The flanking histograms identify the patient situation distribution. The proportion of patients fulfilling at least K2 increased from 22% to 90% (P = 0.006)|
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|Figure 6: Timed Up and Go. The lines depict each patient's before and after situation, with line thickness reflective of patient number. All patients except the one who had implant removal improved their TUG. It is notable that most of the patients who started as wheelchair-bound (assigned a TUG of 40 for graphical purposes) achieved a TUG well interspersed with the patients who were able to walk prior to TOFA|
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|Figure 7: Six-Minute walk test. The lines depict each patient's before and after situation, with each line representing a single patient. Only patients who completed both before and also after tests are represented. All patients improved except the one who had the implant removed. The wheelchair-bound patients improved similarly to or better than the patients who were ambulatory prior to TOFA|
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|Table 4: Mobility performance before lengthening versus after osseointegration|
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[Table 5] reports the QOL survey data of patients before lengthening and after osseointegration. Patients 5 and 10 were excluded due to incomplete data availability. All three categories significantly improved: The global, mobility, and problem domains [Figure 8].
|Figure 8: Questionnaire for persons with a transfemoral amputation survey results. Average scores before and after TOFA, with standard deviation error bars. All three categories improved to a significant confidence. Note that for problem scores, lower is better (less problem burden)|
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|Table 5: Quality of life surveys before lengthening versus after osseointegration|
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| Discussion|| |
The most important finding of this study is that all patients successfully had the tandem procedures of lengthening followed by osseointegration and walked full weight on their prosthetic leg without any compromise of bone integrity. Intramedullary lengthening was an intense journey: The average time from the lengthening surgery until osseointegration was 1 year, and seven patients had additional surgery during lengthening. However, the resultant bone was conducive to osseointegration: Nine of the ten patients remain ambulatory on their osseointegrated prosthetic leg after 2–3.8 years. Importantly, the patients considered the journey worth the effort: QOL significantly improved in all three major domains of the QTFA. Mobility also improved: The K-level and TUG were significantly better, and the daily wear hours and 6MWT also increased, although not to a significant degree.
The literature regarding transfemoral osseointegration is consistent and clear. Patients who are dissatisfied with their TSP are very likely to have significantly improved mobility and QOL after osseointegration.,,,,, The most common complications include infection (which may require oral or intravenous antibiotics, or irrigation and debridement with implant retention or implant removal), periprosthetic fracture (from which patients recover following internal fixation with implant retention),, and implant fracture (which requires remnant implant removal and potential revision osseointegration). The basic science of osseointegration between titanium and normal healthy bone is well enough understood that clinically stable long-term osseointegration is achievable in nearly every patient, with almost all studies reporting on healthy transfemoral amputees. Therefore, two major frontiers remain in the early exploration of osseointegrated limb replacement: Achieving a near-zero infection rate, and better understanding to what extent various health morbidities present risks for long-term successful osseointegration. In just the last few years, it has been proven that osseointegration can be safe and beneficial for patients with disease which traditionally were assumed to be of unacceptable risk for major complications: Vascular disease, prior total knee infection, diabetes mellitus, and irradiated bone.
The current study investigated a different potential risk factor for osseointegration: A prohibitively short residual limb. The biologic phenomenon of osseointegration is defined as "a process whereby clinically asymptomatic rigid fixation of alloplastic materials is achieved, and maintained, in bone during functional loading." The osseointegration process of TOFA exactly what occurs for cementless total joint replacement: Bone grows exceptionally close to a properly surfaced biocompatible implant, achieving clinical stability. It is important to directly iterate that the bone does not directly grow "into" the implant the way creeping substitution incorporates allograft bone, or "onto" the implant using any sort of biological bonding, but instead interdigitates within a sub-micron distance of the implant.,, Many factors that affect the ability of cementless arthroplasty components and other osseointegrated implants to achieve stability also affect TOFA, such as implant-bone positioning, the implant's surface texture, the general metabolic health of the patient and the specific bone, and the total surface area available for bone-implant integration., Two challenges that are nearly unique for TOFA versus other medical instances of osseointegration are the permanent transcutaneous situation, which allows bacteria to invade (which is also a concern for bone-anchored hearing aids) and the mechanical tension force of the weight of the external prosthetic limb that the TOFA system must resist whenever patients lift their extremity (unlinked total joints do not experience similar direct tension forces but rather almost exclusively compressive forces which promote osseointegration between bone and implant). Although experiments and clinical experience have proven that textured titanium surfaces can achieve sufficient osseointegration to resist supraphysiologic pull-out forces,, it is not established what the pull out strength is per area of contact. Further, the clinical reality is that despite even the most meticulous surgical technique, there is no confident way to accurately and precisely assess the amount of actual surface contact between bone and implant. Therefore, clinical intuition and judgment remains the guide for how to best treat patients with short residual bone. It is intuitive that if the intramedullary canal and implant can have matching geometry, then the greater the diameter and length of bone-implant overlap, the greater potential areas available for osseointegration, and therefore, the greater the potential strength to pull-out forces. Such judgment proved sufficient for all patients in this cohort: Regardless of their initial and final femur length, all achieved sufficient bone-implant osseointegration to walk with full weight and none experienced pull-out.
Because this study represents the first known report of distraction histogenesis prior to TOFA, and because of the paucity of directly relevant comparative literature, we feel it is important and appropriate to also share some subjective observations and insights of our experience with this process. First, we admit and emphasize that we are not certain what a minimum length or contact area must be to achieve clinically successful TOFA. It stands to reason that the minimum amount is shorter than our smallest patient's length, as none of these implants gave way or fell out. Since the bone-implant interface strength was never exceeded, by definition all patients had at least some redundant contact area. It is also therefore logical that, perhaps, lengthening may not have been absolutely necessary to optimize a successful outcome for any of all of these patients. The shortest bone at TOFA implantation was 90 mm, shorter than all but one of the initial lengths. Since that patient remained stable, perhaps 90 mm is already more than the minimum requirement, and instead of lengthening patients equivalent stability could have been achieved by instead using customized shorter implant lengths to match the existing patient bone length.
A second insight worthy of discussion is that of regenerate quality. Amputee lengthening is itself a rare procedure, and often fraught with complications. Indeed, we may have been the first to publish on amputee lengthening using intramedullary lengthening nails, with only one other identified study being a more recent case report. The most common complication we encountered was regenerate that appeared radiographically deficient (three patients), which is a potential issue even for patients with complete limbs with both intramedullary and external lengthening., For patients who have intact sensate limbs that can reach the ground, with solid bone and vascularized soft tissue on both sides of the regenerate, it is common to prescribe progressive loading via weight bearing in order to more rapidly strengthen the bone, often guided by the implant's weight limitations. Amputees do not have healthy biology on both sides of their lengthening segment and also cannot achieve partial loading as easily. Further, there was no precedent guiding us to be confident how robust regenerate bone had to be to exchange a lengthening device for an osseointegration implant. Regenerate that is too weak could collapse upon removal of the intramedullary nail. Additionally, although titanium is a bioinert material in and on which bone can grow very well, and the new bone regenerate is very biologically active,, it was unknown whether poorly matured regenerate had sufficient biologic capacity to sufficiently mature on these implants' surfaces. Therefore, to prevent regenerate collapse and ensure a stable length for the maturation of the regenerate, we provided autograft supplementation along with plate stabilization across the lengthening. This strategy did succeed in achieving a sturdy osseointegrated implant, but the plate irritated all patients and required removal.
The limitations of this study are those inherent to observational research of a small cohort. In particular is selection bias: All patients who had residual femurs near or below the standard implant size were lengthened, without a control group of patients with a similarly sized femur which was not lengthened. It is again emphasized that a minimum length or area of bone necessary to support a full weight bearing lower extremity osseointegrated prosthesis is not known – these patients were lengthened to optimize the length available for bone ingrowth – and this study is not intended to establish a minimum necessary length or area. The most significant strength of this study is the complete follow-up of the studied cohort. All patients were followed at least 2 years after their osseointegration, in addition to their time spent lengthening. Although not all formal mobility and survey data was successfully elicited, no patients were lost to follow-up, and although improvements may be under-represented, complications are fully represented. Additionally, we believe the data provide early insight regarding an important question that has not been addressed before in the literature: How to approach osseointegrated reconstruction for amputees with residual lower extremity bones shorter than the standard implant length?
| Conclusions|| |
For patients with a residual femur length that is concerningly short for successful ingrowth into an osseointegration implant, surgical lengthening can be performed to increase the surface area available for implant-bone contact. This technique of lengthening-before-osseointegration proved successful: All patients achieved full weight bearing on their osseointegrated limb, with infection being the only reason to lose full weight bearing ability Amputees may experience more difficulty consolidating regenerate than patients with intact limbs. It must be reiterated that a true "minimum length" for sufficiently robust osseointegration to support full weight bearing is not known, and lengths shorter than those of this study may be adequate.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Hoellwarth JS, Tetsworth K, Rozbruch SR, Handal MB, Coughlan A, Al Muderis M. Osseointegration for amputees: Current implants, techniques, and future directions. JBJS Rev 2020;8:e0043.
Hoellwarth JS, Tetsworth K, Akhtar MA, Al Muderis M. The clinical history and basic science origins of transcutaneous osseointegration for amputees. Adv Orthop 2022;2022:7960559.
Hebert JS, Rehani M, Stiegelmar R. Osseointegration for lower-limb amputation: A systematic review of clinical outcomes. JBJS Rev 2017;5:e10.
Kunutsor SK, Gillatt D, Blom AW. Systematic review of the safety and efficacy of osseointegration prosthesis after limb amputation. Br J Surg 2018;105:1731-41.
Assaf A, Saad M, Daas M, Abdallah J, Abdallah R. Use of narrow-diameter implants in the posterior jaw: A systematic review. Implant Dent 2015;24:294-306.
LeGeros RZ, Craig RG. Strategies to affect bone remodeling: Osteointegration. J Bone Miner Res 1993;8 Suppl 2:S583-96.
Junker R, Dimakis A, Thoneick M, Jansen JA. Effects of implant surface coatings and composition on bone integration: A systematic review. Clin Oral Implants Res 2009;20 Suppl 4:185-206.
Mooney V, Predecki PK, Renning J, Gray J. Skeletal extension of limb prosthetic attachments-problems in tissue reaction. J Biomed Mater Res 1971;5:143-59.
Predecki P, Stephan JE, Auslaender BA, Mooney VL, Kirkland K. Kinetics of bone growth into cylindrical channels in aluminum oxide and titanium. J Biomed Mater Res 1972;6:375-400.
Sheridan GA, Falk DP, Fragomen AT, Rozbruch SR. Motorized Internal Limb-Lengthening (MILL) techniques are superior to alternative limb-lengthening techniques: A systematic review and meta-analysis of the literature. JBJS Open Access 2020;5:e20.00115.
Bell JC, Wolf EJ, Schnall BL, Tis JE, Potter BK. Transfemoral amputations: Is there an effect of residual limb length and orientation on energy expenditure? Clin Orthop Relat Res 2014;472:3055-61.
Hoellwarth JS, Tetsworth K, Al-Jawazneh SS, Al Muderis M. Motorized internal lengthening of long bones: Residual limb lengthening. Tech Orthop 2020;35:209.
Mohamed J, Reetz D, van de Meent H, Schreuder H, Frölke JP, Leijendekkers R. What are the risk factors for mechanical failure and loosening of a transfemoral osseointegrated implant system in patients with a lower-limb amputation? Clin Orthop Relat Res 2022;480:722-31.
Balk EM, Gazula A, Markozannes G, Kimmel HJ, Saldanha IJ, Resnik LJ, et al
. Table 1, Lower Limb Extremity Prosthesis Medicare Functional Classification Levels (K Levels). Providence, RI: Agency for Healthcare Research and Quality (US); 2018.
Podsiadlo D, Richardson S. The timed "Up & Go": A test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991;39:142-8.
Schoppen T, Boonstra A, Groothoff JW, de Vries J, Göeken LN, Eisma WH. The Timed "up and go" test: Reliability and validity in persons with unilateral lower limb amputation. Arch Phys Med Rehabil 1999;80:825-8.
Butland RJ, Pang J, Gross ER, Woodcock AA, Geddes DM. Two-, six-, and 12-minute walking tests in respiratory disease. Br Med J (Clin Res Ed) 1982;284:1607-8.
Lin SJ, Bose NH. Six-minute walk test in persons with transtibial amputation. Arch Phys Med Rehabil 2008;89:2354-9.
Muderis MA, Khemka A, Lord SJ, Van De Meent H, Frolke JP. Safety of osseointegrated implants for transfemoral amputees: A two-center prospective cohort study. J Bone Joint Surg Am 2016;98:900-9.
Reetz D, Atallah R, Mohamed J, van de Meent H, Frölke JP, Leijendekkers R. Safety and performance of bone-anchored prostheses in persons with a transfemoral amputation: A 5-year follow-up study. J Bone Joint Surg Am 2020;102:1329-35.
Atallah R, van de Meent H, Verhamme L, Frölke JP, Leijendekkers RA. Safety, prosthesis wearing time and health-related quality of life of lower extremity bone-anchored prostheses using a press-fit titanium osseointegration implant: A prospective one-year follow-up cohort study. PLoS One 2020;15:e0230027.
Reif TJ, Khabyeh-Hasbani N, Jaime KM, Sheridan GA, Otterburn DM, Rozbruch SR. Early experience with femoral and tibial bone-anchored osseointegration prostheses. JB JS Open Access 2021;6:e21.00072.
Hoellwarth JS, Rozbruch SR. Periprosthetic femur fractures in osseointegration amputees: A report of 2 cases using a modified traction technique. JBJS Case Connect 2021;11:In press.
Hoellwarth JS, Tetsworth K, Kendrew J, Kang NV, van Waes O, Al-Maawi Q, et al
. Periprosthetic osseointegration fractures are infrequent and management is familiar. Bone Joint J 2020;102-B: 162-9.
Akhtar MA, Hoellwarth JS, Al-Jawazneh S, Lu W, Roberts C, Al Muderis M. Transtibial osseointegration for patients with peripheral vascular disease: A case series of 6 patients with minimum 3-year follow-up. JB JS Open Access 2021;6:e20.00113.
Akhtar MA, Hoellwarth JS, Tetsworth K, Oomatia A, Al Muderis M. Osseointegration Following Transfemoral Amputation After Infected Total Knee Replacement: A Case Series of 10 Patients With a Mean Follow-up of 5 Years. Arthroplast Today 2022;16:21-30.
Jawazneh S, Lu W, Al Muderis M. Osseointegrated implants in patients with diabetes mellitus: A case series. Arch Phys Med Rehabil 2017;98:e9. [doi: 10.1016/j.apmr.2017.08.025].
Hoellwarth JS, Tetsworth K, Akhtar MA, Oomatia A, Al Muderis M. Transcutaneous Osseointegration for Oncologic Amputees with and without Radiation Therapy: an Observational Cohort Study. JLLR 2022: In Press.
Zarb GA, Albrektsson T. Osseointegration: A requiem for the periodontal ligament. Int J Periodontics Restorative Dent 1991;11:88-91.
Sennerby L, Thomsen P, Ericson LE. Early tissue response to titanium implants inserted in rabbit cortical bone: Part I Light microscopic obserrvations. J Mater Sci Mater Med 1993;4:240-50.
Holgers KM, Thomsen P, Tjellström A, Ericson LE, Bjursten LM. Morphologic Evaluation of Clinical Long-Term Percutaneous Titanium Implants. International Journal of Oral & Maxillofacial Implants 1994;9.
Sennerby L, Thomsen P, Ericson LE. Ultrastructure of the bone-titanium interface in rabbits. J Mater Sci Mater Med 1992;3:262-71.
Smith SE, Garvin KL, Jardon OM, Kaplan PA. Uncemented total hip arthroplasty. Prospective analysis of the tri-lock femoral component. Clinical orthopaedics and related research. 1991;(269):43-50.
Stepanovska J, Matejka R, Rosina J, Bacakova L, Kolarova H. Treatments for enhancing the biocompatibility of titanium implants. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020;164:23-33.
Aghaloo T, Pi-Anfruns J, Moshaverinia A, Sim D, Grogan T, Hadaya D. The effects of systemic diseases and medications on implant osseointegration: A systematic review. Int J Oral Maxillofac Implants 2019;34:s35-49.
Jeyapalina S, Beck JP, Bloebaum RD, Bachus KN. Progression of bone ingrowth and attachment strength for stability of percutaneous osseointegrated prostheses. Clin Orthop Relat Res 2014;472:2957-65.
Lee BH, Lee C, Kim DG, Choi K, Lee KH, Kim YD. Effect of surface structure on biomechanical properties and osseointegration. Mater Sci Eng C 2008;28:1448-61.
Chavan AS, Al Muderis M, Tetsworth K, Rustamov ID, Hoellwarth JS. Residual Amputee Limb Segment Lengthening: A Systematic Review. JLLR 2022: In Press.
Kuruoglu D, Sems SA, Sampson BP, Carlsen BT. Internal Magnetic Lengthening and Reconstruction with Free TRAM Flap After Traumatic Transfemoral Amputation: A Case Report. JBJS Case Connect 2021;11(2).
Galal S, Shin J, Principe P, Khabyeh-Hasbani N, Mehta R, Hamilton A, et al
. STRYDE versus PRECICE magnetic internal lengthening nail for femur lengthening. Arch Orthop Trauma Surg 2021. [doi: 10.1007/s00402-021-03943-8].
Rozbruch SR, Kleinman D, Fragomen AT, Ilizarov S. Limb lengthening and then insertion of an intramedullary nail: A case-matched comparison. Clin Orthop Relat Res 2008;466:2923-32.
Richardson SS, Schairer WW, Fragomen AT, Rozbruch SR. Cost comparison of femoral distraction osteogenesis with external lengthening over a nail versus internal magnetic lengthening nail. J Am Acad Orthop Surg 2019;27:e430-6.
Tetsworth K, Paley D. Basic science of distraction histogenesis. Curr Opin Orthop 1995;6:61.
Kong LC, Li HA, Kang QL, Li G. An update to the advances in understanding distraction histogenesis: From biological mechanisms to novel clinical applications. J Orthop Transl 2020;25:3-10.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]