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 Table of Contents  
SYSTEMATIC REVIEW
Year : 2022  |  Volume : 8  |  Issue : 3  |  Page : 31-35

Pin site infection: A systematic review on how surgical techniques applying wires and half-pins affects pin site infection


1 Department of Orthopaedics, Bispebjerg Hospital, Copenhagen, Denmark
2 Department of Orthopaedics, Odense University Hospital, Odense, Denmark
3 Department of Orthopaedics, Indraprastha Apollo Hospital, New Delhi, India

Date of Submission09-Nov-2021
Date of Decision28-May-2022
Date of Acceptance27-Jul-2022
Date of Web Publication12-Oct-2022

Correspondence Address:
Ilija Ban
Emdrup Kaervej 9, 2400 Copenhagen
Denmark
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jllr.jllr_34_21

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  Abstract 


Introduction: Pin site infection continues to be a very common problem when treating patients with external fixators. Wire and half-pin insertion technique may influence the risk of developing a pin site infection and the aim of this study is to investigate existing literature in relation to this. Methods: A systematic review of the literature reporting on surgical techniques in relation to pin site infection was conducted. Studies evaluating the effect of a surgical technique with proposed preventive measures to minimize pin site infection in adults and children undergoing an external fixation for trauma or reconstruction were eligible for inclusion. The primary outcome was pin site infection rate. MEDLINE, EMBASE, CINAHL, Google Scholar, and the Cochrane Central Register of Controlled Trials were searched for the period 1970 to August 2021. Study quality was assessed using the modified Downs and Black checklist. A narrative synthesis was undertaken. Results: Two studies describing two different surgical methods were found eligible for inclusion (one cross-sectional study and one prospective cohort). Neither of the two surgical techniques seemed to affect the pin site infection rate. Conclusion: Literature on this topic is sparse, and at present, there is no convincing evidence to support that one surgical technique applying wires and pins is preventive in relation to pin site infection.

Keywords: Pin application, pin site infection, surgical technique, wire application


How to cite this article:
Ban I, Jensen J, Tanwar YS. Pin site infection: A systematic review on how surgical techniques applying wires and half-pins affects pin site infection. J Limb Lengthen Reconstr 2022;8, Suppl S1:31-5

How to cite this URL:
Ban I, Jensen J, Tanwar YS. Pin site infection: A systematic review on how surgical techniques applying wires and half-pins affects pin site infection. J Limb Lengthen Reconstr [serial online] 2022 [cited 2022 Dec 1];8, Suppl S1:31-5. Available from: https://www.jlimblengthrecon.org/text.asp?2022/8/3/31/358263




  Introduction Top


Pin site infection is the most common complication and often a limiting factor associated with external fixators.[1] Risk factors associated with pin site infection are poorly understood but most certainly multifactorial.[2] Intrinsic (host, age, smoking etc.) as well as extrinsic (construct of fixator, duration of an applied external fixator, pin placement etc.) factors seem to affect the risk of pin site infection in a complex way.[3]

Prevention seems to be of paramount importance tackling pin site infection. How to prevent infection optimally is thoroughly debated but several authors state that prevention starts in the operating theater with proper surgical technique.[1],[4],[5],[6] Aseptic no-touch wire handling, irrigation of pilot holes to remove debris, no wire or pin drilling through soft-tissue, use of soft-tissue protection sleeves when drilling, proper skin incisions and heat prevention by continuous saline cooling, no use of tourniquet, predrilling, stop-and-start drilling, and pin insertion by hand have all been proposed as techniques to lower the risk of pin site infection.[3],[4],[5],[7],[8]

The aim of this study was to investigate if surgical techniques, of any kind, for insertion of the pins and wires of an external fixator have any effect on pin site infection based on a review of current literature.


  Methods Top


This systematic review is reported according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines.[9] The protocol was registered before startup and published in the international prospective register of systematic reviews with the ID number CRD42021270301.

Eligibility criteria

Eligibility criteria for inclusion of studies in this review were primarily based on components of a PICO framework:

  • (P) Population: Patients of all ages (adults and pediatric) in whom application of an external fixator (of any kind) was done either due to trauma or reconstruction
  • (I) Intervention: All surgical techniques with proposed preventive measures to lower pin site infection
  • (C) Comparator: Any alternative surgical techniques
  • (O) Outcome: Rate of pin site infection.


Due to expected scarcity of literature, we included studies in all languages and all study types including clinical trials (randomized controlled trial (RCT), nonrandomized controlled trials (nRCT), and all types of observational studies (cohort [prospective and retrospective], case–control, and case series) on human participants published since 1970. We did not include studies comparing two or more different implants such as wires versus half-pin or different coatings of half-pins.

Information sources

A systematic literature search was performed in August 25, 2021, searching the following electronic databases; MEDLINE, EMBASE, CINAHL, Google Scholar, and the Cochrane Central Register of Controlled Trials. In addition, the reference lists of relevant studies were screened for additional eligible articles. Searching Google Scholar, we screened the first 1000 records.

Search strategy

The search strategy included the key terms “external fixator” in combination with “pin site infection” or “pin tract infection.” A more specific search strategy was based on a combination of MESH text words based on (P) population and (O) outcome of the PICO framework:

  • (P): “External fixator” (MESH term) Or “ilizarov technique” (MESH term) Or “external fix*” Or “circular fix*” Or “ilizarov*”
  • (O): “Bone wire” (MESH term) Or “Bone nails” (MESH term) Or “wire*” Or “halfpin*” Or “pin site*” Or “pin tract * And “infections” (MESH term) Or “infect*” Or “sepsi*.”


Study records

Search results were extracted to the electronic reference management program Covidence (Veritas Health Innovation, Melbourne, Australia). Duplicates were removed automatically by the program. Two of the authors independently screened the remaining articles and identified relevant publications based on titles and abstracts. The full versions of potentially relevant articles were read by two authors independently to determine eligibility. Disagreements were resolved with discussion among the three authors. Reasons for exclusion of publications were recorded. None of the authors were blinded to the author affiliation of the screened studies.

Data extraction/collection

Data extractions of all included publications were performed independently by the main author and cross-checked for errors by each of the other two authors. Disagreements were resolved with discussion among the three authors.

Data items

Data of interest for extraction were type of surgical technique for application of wires or half pins, type of external fixator (trauma or reconstruction), rate of pin site infection, and classification used to diagnose a pin site infection.

Study risk of bias assessment

All three authors independently assessed methodological quality using the modified Downs and Black numerical rating scale checklist.[10] This checklist was chosen as it can be used to assess both randomized as well as nonrandomized studies. Quality was assessed based on study quality, external validity, study bias, confounding/selection bias, and power analysis. The modified scale ranges from 0 to 28 with quality levels graded according to Hooper et al.: poor (0–14)), fair, (15–19), good (20–25), and excellent (26–28).[11]

Data synthesis/analysis

Due to scarcity of the included studies and the heterogeneity of interventions investigated, it was not possible to perform a meta-analysis on extracted data. Data were presented descriptively as presented by the individual study.


  Results Top


Our search initially resulted in a total of 3295 studies included for screening of which 1102 were duplicates. Following screening by title/abstract and full-text readings, we ended up with a total of two studies eligible for inclusion. [Figure 1] shows a flowchart diagram of the search strategy and [Table 1] the characteristics of the included studies.
Figure 1: PRISMA flow diagram of search strategy.[9] PRISMA: Preferred Reporting Items for Systematic Review and Meta-Analysis

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Table 1: Study and patient characteristics

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The two studies included were both using pin site infection as the primary outcome. In both studies, infection at pin site was evaluated using the grading score described by Paley.[14] Both studies only included Grade 2 and 3 as pin site infections, excluding Grade 1 (inflammation).

The study by Catagni et al. investigated the difference between applying a half-pin with threads outside the skin compared to a half-pin with threads inside the skin.[12] The study was designed as a one-time evaluation (cross-sectional design) of pin sites with a mean duration of frame application at time of evaluation of 118 days (range, 27–390). The investigators evaluating the pin sites were not blinded to the technique being used. The half-pins were applied in combination with wires on a circular fixator constructed as a modified Ilizarov frame. The half-pins were not applied with threads in-or outside the skin by a predefined randomization method. At the time of evaluation n = 563 half-pins with threads outside the skin were identified and compared to n = 530 half-pins with threads inside the skin. No statistical difference between the two application methods was found in relation to pin site infection (n = 17 infected half-pins [threads outside] vs. n = 17 infected half-pins [threads inside] [P = 0.429]).

The study by Hutchinson et al. investigated the difference between half-pins inserted by direct-drilling or by predrilling followed by hand-insertion.[13] The study was designed as a prospective cohort study. The half-pins were applied as a four-pin two-bar monolateral external fixator to treat distal radius fractures. Each patient had two half-pins applied by direct drilling and two by predrilling using a standardized alteration method based on the patient's medical record number. N =100 half-pin inserted by direct drilling was compared to n = 100 half-pins inserted by predrilling and hand-insertion. Pin site evaluation was made in the office at some point, not specified by the author, during the 6–8 weeks the frame was applied. The investigators evaluating pin site were blinded to the surgical technique that had been used. A total of n = 16 pins sites were infected affecting 13 patients. No statistical difference between the two techniques were found in relation to pin site infection (n = 8 infected half-pins [direct drilled] vs. n = 8 infected half-pins [predrilled] [P = 0.5]).

The methodological quality of both studies was fair according to the Downs and Black numerical rating scale [Table 2].
Table 2: Assessment of quality of studies using Downs and Black checklist[10]

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  Discussion Top


This review highlights that publications investigating surgical techniques for handling wires and pins with external fixators to reduce pin site infection is sparse as only two studies have been included. Previous reviews on prevention of pin site infection do however outline that prevention or minimizing the risk of pin site infection starts in the operating theater with proper surgical technique.[1],[4],[15] Most authors advocating for meticulous surgical technique refer to the same study by Davies et al. from 2005.[5] Davies et al.[5] compared in a prospective setting two different protocols for care of pin sites (British consensus protocol vs. Russian Ilizarov protocol). Both protocols included recommendations for several different measures (both surgical techniques of pin/wire handling and for the pin site aftercare). The study did not elaborate on the effect of each single measure on its own but compared the effect of application of the whole protocol. The authors reported a significant reduction in the rate of pin site infection using the Russian Ilizarov protocol. Although not investigating which measures were most effective (the different surgical techniques or the aftercare) to prevent pin site infection the authors stated, “It should be emphasized that any strategy for reducing infections begins in the operating theater.” Although evidence is sparse, this sentence has been adapted and repeated by several authors. In other cases, it seems that expert opinion and experience with an insertion technique without direct correlation to reduction of pin site infection[6],[7],[8] is adapted in several reviews.[1],[4] The effect of most techniques seems questionable as they have not been evaluated in a study but primarily based on an author's preferable approach.

Our review indicates that only two surgical techniques have been investigated in relation to prevention of pin site infections. Both studies are of low quality which must be acknowledged in interpretation the results. However, based on current evidence it seems that there are no clinical differences whether pins are inserted by direct drilling or by predrilling or if the threads of the pins are left in- or outside the skin. The study by Hutchinson et al. did not find any differences in relation to pin site infection, correlating with their clinical impression they would not recommend direct drilling. Reason for not recommending direct drilling was related to their results from a laboratory study finding significantly elevated temperatures at bone level associated with this technique. In this study laboratory results seems to outweigh clinical results. Both studies used a published classification system for pin site evaluation, but only in one study, the assessors were blinded to the surgical technique used. Furthermore, both studies are very heterogeneous when it comes to type of external fixator (monoliteral vs. circular frame), length of application of external fixator at time of evaluation (weeks vs. months), and indications for application of external fixator (upper limb fracture vs. lower limb fracture and fracture treatment vs. limp reconstruction). This makes it very difficult to make a general conclusion as results based on a monolateral wrist fixator used for 6–8 weeks most likely is not applicable to a circular frame used for lower limp reconstruction when used for 8–12 months.

Based on our review of the current literature, we conclude that the effect of most techniques seems questionable as they are not correlated to a positive effect investigated in a study but primarily based on an author's experience or preferable approach. To investigate the real effect of surgical techniques, we advocate for future studies focusing on the effect of a single surgical technique in a multicenter randomized study with a focus to eliminate confounding factors including different medical conditions for frame application (acute vs. reconstructive and upper vs. lower limb), different frame constructs, different application methods, and different postoperative pin site protocols. We would recommend that pins and wires were applied in the same anatomical locations in all patients using the two different techniques to be compared randomized by pin site. The patient would then be case and control eliminating many confounders.


  Conclusion Top


Pin site infection continues to be a very common problem treating patients with external fixators. Due to implants crossing the skin barrier, infections at pin sites are probably unavoidable. Wire and half-pin insertion technique may influence the risk of developing a pin site infection, but at present, there is no convincing evidence to support this assumption.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Ceroni D, Grumetz C, Desvachez O, Pusateri S, Dunand P, Samara E. From prevention of pin-tract infection to treatment of osteomyelitis during paediatric external fixation. J Child Orthop 2016;10:605-12.  Back to cited text no. 1
    
2.
Moroni A, Vannini F, Mosca M, Giannini S. State of the art review: Techniques to avoid pin loosening and infection in external fixation. J Orthop Trauma 2002;16:189-95.  Back to cited text no. 2
    
3.
Kazmers NH, Fragomen AT, Rozbruch SR. Prevention of pin site infection in external fixation: A review of the literature. Strategies Trauma Limb Reconstr 2016;11:75-85.  Back to cited text no. 3
    
4.
Ferreira N, Marais LC. Prevention and management of external fixator pin track sepsis. Strategies Trauma Limb Reconstr 2012;7:67-72.  Back to cited text no. 4
    
5.
Davies R, Holt N, Nayagam S. The care of pin sites with external fixation. J Bone Joint Surg Br 2005;87:716-9.  Back to cited text no. 5
    
6.
Hutson JJ Jr. Managing infectious complications of Ilizarov fixators. In: Hutson JJ, editor. Techniques in Orthopaedics. Ch. 11. Philadelphia: Lippincott Williams and Wilkins, Inc.; 2002. p. 100-2.  Back to cited text no. 6
    
7.
Rose R. Pin site care with the Ilizarov circular fixator. Internet J Orthop Surg 2009;16.  Back to cited text no. 7
    
8.
Bibbo C, Brueggeman J. Prevention and management of complications arising from external fixation pin sites. J Foot Ankle Surg 2010;49:87-92.  Back to cited text no. 8
    
9.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. J Clin Epidemiol 2021;134:178-89.  Back to cited text no. 9
    
10.
Downs SH, Black N. The feasibility of creating a checklist for the assessment of the interventions. J Epidemiol Community Health 1998;52:377-84.  Back to cited text no. 10
    
11.
Hooper P, Jutai JW, Strong G, Russell-Minda E. Age-related macular degeneration and low-vision rehabilitation: A systematic review. Can J Ophthalmol 2008;43:180-7.  Back to cited text no. 11
    
12.
Catagni MA, Ottaviani G, Combi A, Elhence A. External circular fixation: A comparison of infection rates between wires and conical half-pins with threads outside or inside the skin. J Trauma 2006;61:1186-91.  Back to cited text no. 12
    
13.
Hutchinson DT, Bachus KN, Higgenbotham T. External fixation of the distal radius: To predrill or not to predrill. J Hand Surg Am 2000;25:1064-8.  Back to cited text no. 13
    
14.
Paley D. Problems, obstacles, and complications of limb lengthening by the Ilizarov technique. Clin Orthop Relat Res 1990;(250):81-104.  Back to cited text no. 14
    
15.
Guerado E, Cano JR, Fernandez-Sanchez F. Pin tract infection prophylaxis and treatment. Injury 2019;50 Suppl 1:S45-9.  Back to cited text no. 15
    


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    Tables

  [Table 1], [Table 2]



 

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